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What do they treat?

√ Premises flies

For controlling adult house flies in and around farm buildings, any larvae present are also killed.

Note: √ Moderately toxic to fish and highly toxic to bees (decreases after drying)

How can they be administered?

A variety of application methods for administering pesticide products to cattle are in use.

√ Premises surface spray √ Bait


Reported in: √ House flies (detected overseas, untested in Australia)

Avoid repetitive use of the same chemical group (Oxadiazines belong to IRAC Mode of Action group 22A) to avoid the build-up of resistant individuals within populations.

What is resistance?


Everyone working in the rural industry has a ‘duty of care’; a legal obligation to provide a safe workplace for everyone on the property.

  • Oxadiazines are generally regarded as compounds of moderate to low toxicity with favourable environmental dissipation rates.

Withholding periods are mandatory with all registered veterinary products used to treat animals for internal and external parasites.

Types of oxadiazine

A guide to the different chemical actives and the pests they affect are in Table 1. See choosing and using products for the premises for advice on the appropriate formulation and application method for your target pest.

Table 1. Oxadiazines, active and the targeted parasites for which formulations are registered for.

Chemical Pests targeted (may vary with formulation)
Worms Premises flies* Ticks Lice Mites

*IRAC Mode of Action group 22A

What are they?

Oxadiazines are non-systemic, synthetic organophosphate replacement insecticides used to control insects. They are safer and more insect-effective variations of the highly toxic and environmentally damaging pyrazoline-type insecticides.

How do they work?

Oxadiazines are broad-spectrum insecticides which act by blocking sodium channels in the insect nervous system. This results in impaired nerve function, cessation of feeding, paralysis, and death.

Indoxacarb is absorbed via ingestion with lesser amounts absorbed across the insect cuticle through direct exposure.

Unlike pyrethroid products which have a fast knockdown effect, indoxacarb products are activated by the internal enzymes in target insects which takes up to 24 hours to kill the insect.

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